If your face looks more hollow or less firm while losing weight with medicines such as Mounjaro or Eppe (efpeglenatide), you can consider a facial care plan alongside weight management. Volume support may be considered for hollow cheeks and temples, lifting for a less defined jawline and sagging skin, and skin boosters for dryness and fine lines. Start by choosing care that addresses the changes you notice now.
Why consider facial care while using Mounjaro or Eppe?
As weight decreases, facial volume and the tissues supporting the skin may also change. Shadows in the cheeks can become more pronounced, the temples may look hollow, and the jawline may appear less firm. These changes are often called “Ozempic face,” but assessing the face involves more than the medicine's name: the amount of weight lost, existing facial volume and skin firmness all matter.
Semaglutide, the active ingredient in Wegovy, and efpeglenatide, the active ingredient in Eppe, belong to the GLP-1 class. Tirzepatide, the active ingredient in Mounjaro, acts on both GIP and GLP-1 pathways. On October 7, 2026, Hanmi Pharmaceutical announced Korean marketing approval for Eppe, a GLP-1 obesity medicine developed in Korea.
Facial care is planned by looking separately at remaining volume, firmness and skin texture. Reviewing weight-loss records and earlier facial photographs can help identify which areas need support and which care to consider first.
Choose care during weight loss according to your concerns
| Noticeable change | Care goal | Care to consider |
|---|---|---|
| Hollow cheeks or temples | Support volume in hollow areas and facial balance | Hyaluronic acid fillers, Sculptra, Juvelook Volume and similar options |
| Sagging skin or a less defined jawline | Manage skin firmness and facial contours | Radiofrequency care such as Thermage; focused ultrasound such as Ultherapy |
| Dryness, fine lines or rough skin texture | Manage hydration, texture and firmness according to skin condition | Skin boosters such as Rejuran and Re2o |
1. Hollow cheeks and temples: fillers and collagen-stimulating care
If the cheeks look flatter or shadows at the temples have deepened, first identify the hollow areas and nearby facial contours. Hyaluronic acid fillers are one way to support volume where needed. Future weight-loss plans and previous injection history are reviewed together to determine the areas and amounts to treat.
Collagen-stimulating care such as Sculptra and Juvelook Volume may also be considered. Collagen is a protein that supports the skin; these treatments stimulate changes in skin tissue according to their ingredients and application methods. Their role is distinguished from that of fillers based on where volume support is needed, the desired change and how long you can wait for that change.
A multicenter study of 41 people with cheek wrinkles and midface contour changes after GLP-1 medicine use combined PLLA-based care with hyaluronic acid fillers. Skin measurements and standardized photographs were assessed through nine months after the last PLLA treatment. Improvements were reported in cheek, jawline and perioral contours, as well as skin hydration and other measures.
2. Sagging skin and the jawline: firmness care with Thermage and Ultherapy
If facial volume is not substantially reduced but the skin has become looser or the jawline less defined, improving firmness may be the main focus. Radiofrequency care such as Thermage uses heat energy to manage skin firmness. Focused ultrasound care such as Ultherapy concentrates ultrasound energy at selected depths to treat supporting tissues.
Distinguishing hollow areas from sagging areas helps determine the treatment coverage and depth for each area. If the cheeks have already become thinner, remaining volume is also reviewed. When hollowing and sagging occur together, the sequence of volume support and firmness care is planned in separate steps.
3. Dryness, fine lines and texture: skin boosters such as Rejuran and Re2o
If the skin becomes rougher or fine lines more noticeable during weight loss, skin texture care can also be considered. When reviewing skin boosters such as Rejuran and Re2o, distinguish each product's ingredients and intended use, then identify whether hydration, texture or firmness is the main concern.
Skin boosters are planned to manage skin condition, while volume-supporting care focuses on balance in hollow areas. If hollow cheeks and dryness occur together, distinguishing these two goals helps you choose the options needed.
When should you plan care during weight loss?
1. During ongoing weight loss: proceed in stages as your face changes
Review how much your weight is currently changing and how much more you plan to lose. If facial changes are starting to concern you, record your current condition and consider care for the areas that need it. It is helpful to adjust treatment coverage and sequence as weight loss progresses, rather than deciding on a large change all at once.
2. As weight changes settle: reassess facial balance
Once weight loss stabilizes, reassess remaining hollowing, sagging and skin texture. Decide whether volume support or care for the jawline and skin firmness is the priority, then choose the necessary combination. The starting point is determined by weight changes, skin condition, nutrition and recovery circumstances together, rather than a fixed number of months.
Even if you eat less, include protein-containing foods such as eggs, tofu and fish. Continue strength training suited to your fitness, moisturizing and sun protection. Follow the prescribing clinic's guidance on medication doses and dose increases.
Review the care you need at CELITA Clinic
CELITA Clinic reviews AI skin measurement results alongside your current concerns and explains a plan focused on the care you need now. If you use medicines such as Mounjaro or Eppe, share the medicine's name, how long you have used it, recent weight changes and further weight-loss goals. Bringing earlier facial photographs and your injection treatment history can help establish care priorities.
Start by explaining whether your main concern is hollow cheeks, jawline firmness, or dryness and fine lines. After reviewing the areas and goals separately, we explain suitable options among volume support, lifting and skin boosters.
Points to check before and after care
Injection treatments may cause swelling, bruising or tenderness, while device-based treatments may cause redness or a feeling of warmth. If you have an important event coming up, first review the recovery guidance for your chosen method. Also disclose inflammation or wounds in the treatment area, pregnancy or breastfeeding, current medicines and previous treatments in advance.
Frequently Asked Questions
Q. Can I have fillers or lifting while using Mounjaro?
Care can be considered after reviewing your medicines, weight changes, skin condition and previous treatments together. Share your weight-loss plan and determine the treatment areas, amounts and sequence.
Q. Should I also consider facial care while using Eppe?
Eppe is a GLP-1 medicine containing efpeglenatide. If hollow cheeks, sagging, dryness or fine lines concern you during use, you can explore care according to your current facial condition.
Q. For hollow cheeks, should I choose lifting or fillers first?
If reduced volume is the main issue, consider volume support first. If sagging skin is the main issue, consider firmness care first. When both are present, determine the sequence by assessing hollow and sagging areas separately.
Q. What concerns do skin boosters such as Rejuran and Re2o address?
Check each product's ingredients and intended use, and choose according to goals such as skin texture and firmness. If deep cheek hollowing is the main concern, separately assess whether volume support is also needed.
Q. Do I need to reach my target weight before starting care?
Care for areas that need it can be considered during weight loss. Adjust coverage and sequence according to further weight-loss plans and current changes, then reassess facial balance once weight changes stabilize.
Q. Do I need fillers, lifting and skin boosters all together?
Choose the options needed according to the changes that concern you most and your skin condition. Separating the goals of volume support, firmness and skin texture makes it easier to decide which care to start first.
Key Takeaways
- If you are losing weight with medicines such as Mounjaro or Eppe, also review facial volume, firmness and skin texture.
- Consider volume support for hollow cheeks, lifting for sagging, and skin boosters for dryness and fine lines.
- Plan care first for the areas that need it, according to your weight-loss stage and current facial condition.
Contact CELITA Clinic if you want to review facial contours alongside weight management. Share your current weight-loss plan and facial concerns so we can explore the care you may need.
Appointments and Enquiries
Contact us on WhatsApp: https://wa.me/821046019442. Before visiting, review your questions and skin care plan with us.
This post provides general skin information. Treatment effects and side effects may vary from person to person. Please contact CELITA Clinic to discuss whether care is needed.
